Perbandingan Antara Pregabalin Dengan Ibuprofen terhadap Kadar Neutrofil Pascabedah Laparotomi Ginekologi
DOI:
https://doi.org/10.33096/a7r5ac07Keywords:
Ibuprofen , Laparotomi, Neutrofil, PregabalinAbstract
Postoperative pain is an important problem frequently encountered in postoperative patients. Although understanding of the mechanisms of postoperative pain has advanced considerably, postoperative pain management remains suboptimal and is often neglected. Preemptive analgesia refers to the administration of analgesic interventions before nociceptive stimulation occurs, with the aim of preventing pain, suppressing sensory afferent input, reducing central nervous system sensitization, and minimizing postoperative pain effects. This study aimed to compare pregabalin and ibuprofen as preemptive analgesia on neutrophil levels after gynecological laparotomy. This was an experimental clinical trial using a pre-post test control design, in which variables were measured before and after the intervention. The collected data were analyzed using paired t-test and independent t-test. The results showed no significant difference in the increase of neutrophil levels between ibuprofen and pregabalin administration, with a p-value of 0.237. However, the increase in neutrophil levels was higher in the pregabalin group than in the ibuprofen group, namely 683.60 ± 1501.13 compared with 532.82 ± 527.67. Therefore, it can be concluded that there was no significant difference in the increase of neutrophil levels between pregabalin and ibuprofen administration in patients undergoing gynecological laparotomy, although the increase in neutrophil levels was higher in the pregabalin group than in the ibuprofen group.
References
1. Putra IWME. Manajemen Nyeri Pascabedah dalam Protokol Enhanced Recovery After Surgery (Eras): Pendekatan Analgesia Multimodal. J Comperehensive Sci. 2025;4(12):3313–20.
2. Rachmadina T, Muladi A. Manajemen Nyeri Farmakologi pada Pasien Pasca Pembedahan Open Reduction Internal Fixation (Orif) Ekstermias Atas dengan General Anestesi. Vitam J Ilmu Kesehat Umum. 2025;3(3):240–6.
3. Harahap MW, Dwimartyono F, Susilo W, Ekawati F. Perbandingan antara Ibuprofen dengan Ketorolak Intravena terhadap Kadar Neutrofil Pascabedah Laparotomi Genekologi. UMI Med J. 2023;8(2):101–8.
4. Setiyowati DA, Maringga EG. Asuhan Kebidanan Pada Ibu Nifas Post SC Dengan Nyeri Luka Jahitan Di Wilayah Kerja Rumah Sakit Amelia Kabupaten Kediri. J Kebidanan Manna. 2022;1(2):51–6.
5. Harahap MW, Gaus S, Ahmad MR, Husain AAA, Wirawan NS. Perbandingan antara Pregabalin 50 mg dengan 75 mg terhadap Derajat Nyeri dan Rescue Analgesia Pascabedah Seksio Sesarea. J Anastesi Obs Indones. 2022;5(2):76–82.
6. Product N. Penggunaan Gabapentin dan Pregabalin sebagai Terapi Adjuvant pada Pasien Nyeri di Instalasi Rawat Inap Rumah Sakit Umum Daerah Ungaran. Indones J Pharmasi Nat Prod. 2025;08(1):23–9.
7. Arfania M, Friyanto D, Musfiroh EN, Stathi’ah FA, Irawan L, Yuliani ND, et al. Efek Samping Terhadap Pemakaian Analgetik Golongan Nsaid (Ibu Profen). Innov J Soc Sci Res. 2023;3(2):8065–75.
8. Yasli AS, Rahayu MS, Siregar SR. Effectiveness of Propolis in Protecting Against Gastric Ulcers in Male Wistar Rats (Rattus norvegicus) Induced Ibuprofen. J Pharm Sci. 2025;8(4):2806–14.
9. Rahim MR, Musba AMT, Palinrungi AS, Ahmad MR, Rum M, R R. Perbandingan antara Kombinasi Ibuprofen dan Parasetamol dengan Ketorolak dan Paracetamol Intravena terhadap Derajat Nyeri dan Rasio Neutrofil Limfosit Pasca-Functional Endoscopic Sinus Surgery. J Anastesi Perioper. 2024;12(3):161–8.
10. Sirajuddin A, Ahmad MR, Gaus S. Comparison of the Effects of Pre-Emtif Analgesia Pregabaline 75 with 150mg on The Trade of Pain and Caesarian Section Sedation Score with Subarakhnoid Block. J Kesehat. 2022;15(1):58–64.
11. Abdulkhaleq LA, Assi MA, Abdullah R, M.Zamri-Saad, Taufiq-Yap YH, Hezmee MNM. The Crucial Roles of Inflammatory Mediators in Inflammation : A review. Vet World. 2018;11(5):627–35.
12. Harahap MW, Ahmad MR. Perbandingan antara Dexametason dan Metamizol Intravena terhadap Kadar Neutrofil Pasca Seksio Sesarea. J Anastesi Obs Indones. 2022;5(3):142–7.
13. N N, Awik PD, Rihandoko A, Santoso M, Setiawan E. Visualisasi Interaksi Ligan Ibuprofen terhadap Protein Cyclooxygenase secara Komputasi. Proceeding Biol Educ Conf. 2019;16(1):176–9.
14. Li Z, Li X, Liu J, Sun R, Ye Y, Xiang H, et al. Molecular Mechanisms of Chronic Pain and Therapeutic Interventions. MedComm [Internet]. 2025;6(8):e70325. Available from: https://doi.org/10.1002/mco2.70325
15. Wu Q, Cui X, Guan LC, Zhang C, Liu J, Ford NC, et al. Chronic Pain After Spine Surgery : Insights into Pathogenesis , New Treatment , and Preventive Therapy. J Orthop Transl [Internet]. 2023;42(July):147–59. Available from: https://doi.org/10.1016/j.jot.2023.07.003
